Exploring timing activation of functional pathway based on differential co-expression analysis in preimplantation embryogenesis.

ABSTRACT: Recent genome-wide omics studies have confirmed the early embryogenesis strictly dependent on the rigorous spatiotemporal activation and multilevel regulation. However, the full effect of functional pathway was not considered. To obtain complete understanding of the gene activation during early development, we performed systematic comparisons based on differential co-expression analysis for bovine preimplantation embryo development (PED). The results confirmed that the functional pathways actively transcribes as early as the 2-cell and 4-cell waves, which Basal transcription factor, Endocytosis and Spliceosome pathway can represent first signs of embryonic activity. Endocytosis act as one of master activators for uncovering a series of successive waves of maternal pioneer signal regulator

SUBMITTER: Zuo Y 

PROVIDER: S-EPMC5342040 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature