Blood RNA expression profiles undergo major changes during the seventh decade.

ABSTRACT: Genome-wide alterations in RNA expression profiles are age-associated. Yet the rate and temporal pattern of those alterations are poorly understood. We investigated temporal changes in RNA expression profiles in blood from population-based studies using a quadratic regression model. Comparative analysis between two independent studies was carried out after sample-weighting that downsized differences in sample distribution over age between the datasets. We show that age-associated expression profiles are clustered into two major inclinations and transcriptional alternations occur predominantly from the seventh decade onwards. The age-associated genes in blood are enriched in functional groups of the translational machinery and the immune system. The results are highly consistent between the

SUBMITTER: Gheorghe M 

PROVIDER: S-EPMC5342083 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature