Blockade of the Hedgehog pathway downregulates estrogen receptor alpha signaling in breast cancer cells.

ABSTRACT: Anti-estrogen treatment, exemplified by tamoxifen, is a well-established adjuvant therapy for estrogen receptor alpha (ERα)-positive breast cancer. However, the effectiveness of this drug is limited due to the development of resistance. The Hedgehog (HH) signaling pathway is critical in embryonic development, and aberrant activation of this transduction cascade is linked to various malignancies. However, it remains unclear whether HH signaling is activated in human breast cancer and related to tamoxifen resistance. Deciphering how this pathway may be involved in breast cancer is a crucial step towards the establishment of targeted combinatorial treatments for this disease. Here, we show that the expression of the HH signaling effector protein GLI1 is higher in tamoxifen resistant compared

SUBMITTER: Diao Y 

PROVIDER: S-EPMC5342103 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature