Progressive changes in composition of lymphocytes in lung tissues from patients with non-small-cell lung cancer.

ABSTRACT: Immune cell infiltration is a common feature of many human solid tumors. Innate and adaptative immune systems contribute to tumor immunosurveillance. We investigated whether tumors evade immune surveillance by inducing states of tolerance and/or through the inability of some immune subpopulations to effectively penetrate tumor nests. Immunohistochemistry and flow cytometry analysis were used to study the composition and distribution of immune subpopulations in samples of peripheral blood, tumor tissue (TT), adjacent tumor tissue (ATT), distant non-tumor tissue (DNTT), cancer nests, cancer stroma, and invasive margin in 61 non-small-cell lung cancer (NSCLC) patients. A significantly higher percentage of T and B cells and significantly lower percentage of NK cells were detected in TT than in

SUBMITTER: Del Mar Valenzuela-Membrives M 

PROVIDER: S-EPMC5342105 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature