IL-10 secreted by M2 macrophage promoted tumorigenesis through interaction with JAK2 in glioma.

ABSTRACT: M2 tumor-associated macrophage has been found to play a supportive role in the progression of glioma. The underlying mechanism, nevertheless, has been largely unknown. In our study, to investigate how M2 macrophage played role in glioma, firstly we've analyzed the clinicopathological significance of M2 macrophage existence on clinical tissues of glioma using detection of CD163 expression with immunohistochemistry. Then, we've artificially induced M2 macrophage from human monocyte cell line THP-1, followed by co-culture with glioma cell lines in vitro. It was found that M2 macrophage was shown to be markedly distributed in glioma relative to paired normal control; and high prevalence of M2 macrophage was significantly associated with poorer overall survival and tumor progression. Moreover,

SUBMITTER: Qi L 

PROVIDER: S-EPMC5342110 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature