Increased gene expression noise in human cancers is correlated with low p53 and immune activities as well as late stage cancer.

ABSTRACT: Gene expression in metazoans is delicately organized. As genetic information transmits from DNA to RNA and protein, expression noise is inevitably generated. Recent studies begin to unveil the mechanisms of gene expression noise control, but the changes of gene expression precision in pathologic conditions like cancers are unknown. Here we analyzed the transcriptomic data of human breast, liver, lung and colon cancers, and found that the expression noise of more than 74.9% genes was increased in cancer tissues as compared to adjacent normal tissues. This suggested that gene expression precision controlling collapsed during cancer development. A set of 269 genes with noise increased more than 2-fold were identified across different cancer types. These genes were involved in cell adhesion, c

SUBMITTER: Han R 

PROVIDER: S-EPMC5342140 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature