Increased Rab35 expression is a potential biomarker and implicated in the pathogenesis of Parkinson's disease.

ABSTRACT: Parkinson's disease (PD) is the second common neurodegenerative disease. Identification of biomarkers for early diagnosis and prediction of disease progression is important. The present comparative proteomic study of serum samples using two-dimensional fluorescence differential gel electrophoresis followed by ELISA confirmation demonstrated that protein expression of Rab35 was increased in PD patients compared with matched control subjects and other parkinsonian disorders, progressive supranuclear palsy (PSP) and multiple system atrophy (MSA). The serum level of Rab35 was significantly correlated with the age at onset of PD. The median age of onset in patients with higher Rab35 serum level was 5 years younger than those with lower Rab35 serum level. There was a positive correlation between

SUBMITTER: Chiu CC 

PROVIDER: S-EPMC5342336 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature