MiRNA-193a-5p repression of p73 controls Cisplatin chemoresistance in primary bone tumors.

ABSTRACT: Osteosarcoma and Ewing Sarcoma are the two most common types of Bone Sarcomas, principally localized at the long bones of the extremities and mainly affecting adolescents and young adults. Cisplatin is one of the current options in the therapeutic arsenal of drugs available to cure these aggressive cancers. Unfortunately, chemoresistance against this agent is still a major cause of patient relapse. Thus, a better understanding of the molecular pathways by which these drugs induce cancer cell death, together with a better delineation of the origins of chemoresistance are required to improve the success rate of current treatments. Furthermore, as p53 is frequently mutated in Bone Sarcomas, other pathways in these cancers must mediate drug-induced cell death. Here, we demonstrate for the firs

SUBMITTER: Jacques C 

PROVIDER: S-EPMC5342358 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature