Expression of CDX2 in gastric cardia adenocarcinoma and its correlation with H. pylori and cell proliferation.

ABSTRACT:

Background

Gastric cardia cancer (GCC) is located in the distal stomach, and strongly correlates with atrophic gastritis and Helicobacter pylori (H.pylori) infection. Caudal-related homeobox transcription factor 2 (CDX2) is homeobox gene encoding an intestine-specific transcription factor usually expressed in the intestinal epithelium cells. However, in several recent published papers, CDX2 was found to be aberrantly expressed in gastric, thyroid and ovarian cancer.

Results

Higher expression of CDX2 was found in GCC tissues in comparison with non-malignant cardia mucosa (p<0.05). Moreover, immunohistochemical analysis demonstrated that CDX2 expression correlated with lymphatic metastasis. In addition, we found that CDX2 expression progressively increased with the level of H.

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC5342395 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature