CEACAM6 is upregulated by Helicobacter pylori CagA and is a biomarker for early gastric cancer.

ABSTRACT: Early detection of gastric cancers saves lives, but remains a diagnostic challenge. In this study, we aimed to identify cell-surface biomarkers of early gastric cancer. We hypothesized that a subset of plasma membrane proteins induced by the Helicobacter pylori oncoprotein CagA will be retained in early gastric cancers through non-oncogene addiction. An inducible system for expression of CagA was used to identify differentially upregulated membrane protein transcripts in vitro. The top hits were then analyzed in gene expression datasets comparing transcriptome of gastric cancer with normal tissue, to focus on markers retained in cancer. Among the transcripts enriched upon CagA induction in vitro, a significant elevation of CEACAM6 was noted in gene expression datasets of gastric cancer. We

SUBMITTER: Roy RK 

PROVIDER: S-EPMC5342417 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature