Identification of biomarkers for pseudo and true progression of GBM based on radiogenomics study.

ABSTRACT: The diagnosis for pseudoprogression (PsP) and true tumor progression (TTP) of GBM is a challenging task in clinical practices. The purpose of this study is to identify potential genetic biomarkers associated with PsP and TTP based on the clinical records, longitudinal imaging features, and genomics data. We are the first to introduce the radiogenomics approach to identify candidate genes for PsP and TTP of GBM. Specifically, a novel longitudinal sparse regression model was developed to construct the relationship between gene expression and imaging features. The imaging features were extracted from tumors along the longitudinal MRI and provided diagnostic information of PsP and TTP. The 33 candidate genes were selected based on their association with the imaging features, reflecting their r

SUBMITTER: Qian X 

PROVIDER: S-EPMC5342424 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature