Decreased expression of FOXF2 as new predictor of poor prognosis in stage I non-small cell lung cancer.

ABSTRACT:

Background

Forkhead box F2 (FOXF2) is relatively limited to the adult lung, but its contribution to non-small cell lung cancer (NSCLC) prognosis is unclear.

Results

FOXF2 mRNA levels in NSCLC were lower than that in paired normal lung tissues (P = 0.012). The FOXF2low patients had shorter survival time than the FOXF2high patients (P = 0.024) especially in stage I (P = 0.002), chemotherapy (P = 0.018) and < 60 age groups (P = 0.002). Lower FOXF2 mRNA levels could independently predict poorer survival for patients with NSCLC (HR = 2.384, 95% CI = 1.241-4.577; P = 0.009), especially in stage I (HR =4.367, 95% CI =1.599-11.925; P = 0.004). The two independent datasets confirmed our findings.

Methods

We examined FOXF2 mRNA levels in 84 primary NSCLC and 8 normal lung tissu

SUBMITTER: Kong PZ 

PROVIDER: S-EPMC5342439 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature