A panel of 13-miRNA signature as a potential biomarker for predicting survival in pancreatic cancer.

ABSTRACT: Some reports have evaluated the prognostic relevance of microRNAs (miRNAs) in patients with pancreatic cancer (PC). However, most studies focused on limited miRNAs with small number of patients. The aim of the study is to identify a panel of miRNA signature that could predict prognosis in PC with the data from The Cancer Genome Atlas (TCGA). A total of 167 PC patients with the corresponding clinical data were enrolled in our study. The miRNAs significantly associated with overall survival (OS) in PC patients were identified with Cox proportional regression model. A risk score formula was developed to evaluate the prognostic value of the miRNA signature in PC. Thirteen miRNAs were identified to be significantly related with OS in PC patients. Patients with high risk score suffered poor over

SUBMITTER: Zhou X 

PROVIDER: S-EPMC5342502 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature