IOri-Human: identify human origin of replication by incorporating dinucleotide physicochemical properties into pseudo nucleotide composition.

ABSTRACT: The initiation of replication is an extremely important process in DNA life cycle. Given an uncharacterized DNA sequence, can we identify where its origin of replication (ORI) is located? It is no doubt a fundamental problem in genome analysis. Particularly, with the rapid development of genome sequencing technology that results in a huge amount of sequence data, it is highly desired to develop computational methods for rapidly and effectively identifying the ORIs in these genomes. Unfortunately, by means of the existing computational methods, such as sequence alignment or kmer strategies, it could hardly achieve decent success rates. To address this problem, we developed a predictor called "iOri-Human". Rigorous jackknife tests have shown that its overall accuracy and stability in identif

SUBMITTER: Zhang CJ 

PROVIDER: S-EPMC5342515 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature