The clock gene PER1 plays an important role in regulating the clock gene network in human oral squamous cell carcinoma cells.

ABSTRACT: The various clock genes in normal cells, through their interaction, establish a number of positive and negative feedback loops that compose a network structure. These genes play an important role in regulating normal physiological activities. The expression of clock gene PER1 is decreased in many types of cancer. PER1 is highly correlated with the initiation and progression of cancer by regulating numerous downstream genes. However, it is still unclear whether the lower expression of PER1 in cancer can influence the expression of other clock genes in the clock gene network. In this study, we used short hairpin RNA interference to knock down PER1 effectively in SCC15 human oral squamous cell carcinoma cells. These cancer cells later were subcutaneously injected into the back of nude mice. W

SUBMITTER: Zhao Q 

PROVIDER: S-EPMC5342553 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature