Influence of CFH gene on symptom severity of schizophrenia.

ABSTRACT:

Objective

Recent advances have provided compelling evidence for the role of excessive complement activity in the pathophysiology of schizophrenia. In this study, we aimed to detect the association of the gene encoding complement factor H (CFH), a regulator in complement activation, with schizophrenia.

Materials and methods

A sample of 1783 individuals with or without schizophrenia was recruited for genetic analysis. Genomic DNA samples were extracted from peripheral blood cells using multiplex polymerase chain reaction and the SNaPshot assay. A Database for Schizophrenia Genetic Research (SZDB) was used to detect the association of brain CFH expression with schizophrenia. Next, we performed a genotype-phenotype analysis to identify the relationship between C

SUBMITTER: Zhang C 

PROVIDER: S-EPMC5342610 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature