Wearable/disposable sweat-based glucose monitoring device with multistage transdermal drug delivery module.

ABSTRACT: Electrochemical analysis of sweat using soft bioelectronics on human skin provides a new route for noninvasive glucose monitoring without painful blood collection. However, sweat-based glucose sensing still faces many challenges, such as difficulty in sweat collection, activity variation of glucose oxidase due to lactic acid secretion and ambient temperature changes, and delamination of the enzyme when exposed to mechanical friction and skin deformation. Precise point-of-care therapy in response to the measured glucose levels is still very challenging. We present a wearable/disposable sweat-based glucose monitoring device integrated with a feedback transdermal drug delivery module. Careful multilayer patch design and miniaturization of sensors increase the efficiency of the sweat collectio

SUBMITTER: Lee H 

PROVIDER: S-EPMC5342654 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature