In vitro assessment of the glucose-lowering effects of berberrubine-9-O-β-D-glucuronide, an active metabolite of berberrubine.

ABSTRACT: Berberrubine (BRB) is the primary metabolite of berberine (BBR) that has shown a stronger glucose-lowering effect than BBR in vivo. On the other hand, BRB is quickly and extensively metabolized into berberrubine-9-O-β-D-glucuronide (BRBG) in rats after oral administration. In this study we compared the pharmacokinetic properties of BRB and BRBG in rats, and explored the mechanisms underlying their glucose-lowering activities. C57BL/6 mice with HFD-induced hyperglycemia were administered BRB (50 mg·kg^-1·d^-1, ig) for 6 weeks, which caused greater reduction in the plasma glucose levels than those caused by BBR (120 mg·kg^-1·d^-1) or BRB (25 mg·kg^-1·d^-1). In addition, BRB dose-dependently decreased the activity of α-glucosidase in

SUBMITTER: Yang N 

PROVIDER: S-EPMC5342660 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature