Luteolin-7-diglucuronide attenuates isoproterenol-induced myocardial injury and fibrosis in mice.

ABSTRACT: Myocardial injury and ensuing fibrotic alterations impair normal heart architecture and cause cardiac dysfunction. Oxidative stress has been recognized as a key player in the pathogenesis of cardiac injury and progression of cardiac dysfunction, and promoting fibrosis. In the current study we investigated whether luteolin-7-diglucuronide (L7DG), a naturally occurring antioxidant found in edible plants, could attenuate isoproterenol (ISO)-induced myocardial injury and fibrosis in mice and the underlying mechanisms. Myocardial injury and fibrosis were induced in mice via injection of ISO (5 mg·kg^-1·d^-1, ip) for 5 or 10 d. Two treatment regimens (pretreatment and posttreatment) were employed to administer L7DG (5-40 mg·kg^-1·d^-1, ip) into the mice. A

SUBMITTER: Ning BB 

PROVIDER: S-EPMC5342667 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature