Detection of cellular senescence within human invasive breast carcinomas distinguishes different breast tumor subtypes.

ABSTRACT: Oncogene-induced senescence is thought to act as a barrier to tumorigenesis by arresting cells at risk of malignant transformation. Nevertheless, numerous findings suggest that senescent cells may conversely promote tumor progression through the development of the senescence-associated secretome they produce. It is likely that the composition and the physiological consequences mediated by the senescence secretome are dependent on the oncogenes that trigger the senescence program. Breast cancer represents a heterogenous disease that can be divided into breast cancer subtypes due to different subsets of genetic and epigenetic abnormalities. As tumor initiation and progression of these breast cancer subtypes is triggered by diverse oncogenic stimuli, differences in the senescence secretomes w

SUBMITTER: Cotarelo CL 

PROVIDER: S-EPMC5342706 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature