The transcriptional signature of human ovarian carcinoma macrophages is associated with extracellular matrix reorganization.

ABSTRACT: Macrophages occur as resident cells of fetal origin or as infiltrating blood monocyte-derived cells. Despite the critical role of tumor-associated macrophages (TAMs) in tumor progression, the contribution of these developmentally and functionally distinct macrophage subsets and their alteration by the tumor microenvironment are poorly understood. We have addressed this question by comparing TAMs from human ovarian carcinoma ascites, resident peritoneal macrophages (pMPHs) and monocyte-derived macrophages (MDMs). Our study revealed striking a similarity between TAMs and pMPHs, which was considerably greater that the resemblance of TAMs and MDMs, including their transcriptomes, their inflammation-related activation state, the presence of receptors mediating immune functions and the expressio

SUBMITTER: Finkernagel F 

PROVIDER: S-EPMC5342745 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature