SMAD7 polymorphisms and colorectal cancer risk: a meta-analysis of case-control studies.

ABSTRACT: Mothers against decapentaplegic homolog 7 (SMAD7) inhibits the transforming growth factor-β (TGF-β) signaling pathway, which regulates carcinogenesis and cancer progression. A number of studies have reported that SMAD7 polymorphisms (rs4464148, rs4939827, and rs12953717) are associated with colorectal cancer (CRC) risk, but the results from these studies remain conflicting. To determine a more precise estimation of the relationship between SMAD7 and CRC, we undertook a large-scale meta-analysis of 63 studies, which included a total of 187,181 subjects (86,585 cases and 100,596 controls). The results of our meta-analysis revealed that the C allele of rs4464148 [CC vs. TT+TC, odds ratio (OR) =1.23, 95% confidence interval (CI): 1.14-1.33, P < 0.01], the T allele of rs4939827 [TT vs. CC+TC, o

SUBMITTER: Huang Y 

PROVIDER: S-EPMC5342761 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature