Prognostic significance of AMPK in human malignancies: A meta-analysis.

ABSTRACT:

Background

AMPK is a well-investigated kinase mediating cellular metabolism and stress responses. However, its indicative role in survival prognosis remains ill-defined. Therefore we performed this meta-analysis in order to clarify the prognostic impact of AMPK expression in human malignancies.

Methods

Literatures were retrieved via searching databases of PubMed, Web of Science, Embase and Cochrane Library. Studies comparing the prognostic significance between different AMPK levels among human malignancies were included into the pooled analysis. The statistical procedures were conducted by Review Manager 5.3 and the effect size was displayed by model of odds ratio. Subgroup analyses were additionally implemented to disclose the potential confounding elements. The outcome sta

SUBMITTER: Cheng J 

PROVIDER: S-EPMC5342774 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature