Exploring the interactions of the RAS family in the human protein network and their potential implications in RAS-directed therapies.

ABSTRACT: RAS proteins are the founding members of the RAS superfamily of GTPases. They are involved in key signaling pathways regulating essential cellular functions such as cell growth and differentiation. As a result, their deregulation by inactivating mutations often results in aberrant cell proliferation and cancer. With the exception of the relatively well-known KRAS, HRAS and NRAS proteins, little is known about how the interactions of the other RAS human paralogs affect cancer evolution and response to treatment. In this study we performed a comprehensive analysis of the relationship between the phylogeny of RAS proteins and their location in the protein interaction network. This analysis was integrated with the structural analysis of conserved positions in available 3D structures of RAS com

SUBMITTER: Bueno A 

PROVIDER: S-EPMC5342780 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature