PITX2 and PANCR DNA methylation predicts overall survival in patients with head and neck squamous cell carcinoma.

ABSTRACT:

Background

Squamous cell carcinoma of the head and neck region (HNSCC) is a common malignant disease accompanied by a high risk of local or distant recurrence after curative-intent treatment. Biomarkers that allow for the prediction of disease outcome can guide clinicians with respect to treatment and surveillance strategies. Here, the methylation status of PITX2 and an adjacent lncRNA (PANCR) were evaluated for their ability to predict overall survival in HNSCC patients.

Results

PITX2 hypermethylation was associated with a better overall survival (hazard ratio, HR = 0.51, 95%CI: 0.35-0.74, p<0.001), while PANCR hypermethylation was significantly associated with an increased risk of death (HR = 1.64, 95%CI: 1.12-2.39, p=0.010).

Methods

Quantitative, methylation-specif

SUBMITTER: Sailer V 

PROVIDER: S-EPMC5342781 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature