Pesticide use and risk of end-stage renal disease among licensed pesticide applicators in the Agricultural Health Study.

ABSTRACT:

Objectives

Experimental studies suggest a relationship between pesticide exposure and renal impairment, but epidemiological evidence is limited. We evaluated the association between exposure to 39 specific pesticides and end-stage renal disease (ESRD) incidence in the Agricultural Health Study, a prospective cohort study of licensed pesticide applicators in Iowa and North Carolina.

Methods

Via linkage to the US Renal Data System, we identified 320 ESRD cases diagnosed between enrolment (1993-1997) and December 2011 among 55 580 male licensed pesticide applicators. Participants provided information on use of pesticides via self-administered questionnaires. Lifetime pesticide use was defined as the product of duration and frequency of use and then modified by an intensity fact

SUBMITTER: Lebov JF 

PROVIDER: S-EPMC5342837 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature