Reduced perfusion in Broca's area in developmental stuttering.

ABSTRACT:

Objective

To study resting cerebral blood flow in children and adults with developmental stuttering.

Methods

We acquired pulsed arterial spin labeling magnetic resonance imaging data in 26 participants with stuttering and 36 healthy, fluent controls. While covarying for age, sex, and IQ, we compared perfusion values voxel-wise across diagnostic groups and assessed correlations of perfusion with stuttering severity within the stuttering group and with measures of motor speed in both groups.

Results

We detected lower regional Cerebral Blood Flow (rCBF) at rest in the stuttering group compared with healthy controls in Broca's area bilaterally and the superior frontal gyrus. rCBF values in Broca's area bilaterally correlated inversely with the severity of stuttering and e

SUBMITTER: Desai J 

PROVIDER: S-EPMC5342907 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature