A Prospective Study of Smoking and Risk of Synchronous Colorectal Cancers.

ABSTRACT:

Objectives

Cigarette smoking has been linked to somatic genetic and epigenetic aberrations, including CpG island methylator phenotype (CIMP)-high, microsatellite instability (MSI)-high and BRAF mutation. These molecular features have been associated with synchronous primary colorectal cancers (CRCs). Thus, we examined the hypothesis that smoking might be associated with the risk of synchronous CRCs.

Methods

Within the Health Professionals Follow-up Study and Nurses' Health Study, we examined the relationship of smoking and incidence of CRC according to tumor synchronicity, using duplication-method Cox proportional hazards regression analysis.

Results

We confirmed 1,981 solitary CRC and 45 synchronous CRC cases during follow-up of 134,305 individuals. CRC risk associat

SUBMITTER: Drew DA 

PROVIDER: S-EPMC5342916 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature