β Cells that Resist Immunological Attack Develop during Progression of Autoimmune Diabetes in NOD Mice.
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ABSTRACT:
SUBMITTER: Rui J
PROVIDER: S-EPMC5342930 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
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β Cells that Resist Immunological Attack Develop during Progression of Autoimmune Diabetes in NOD Mice.
Rui Jinxiu J Deng Songyan S Arazi Arnon A Perdigoto Ana Luisa AL Liu Zongzhi Z Herold Kevan C KC
Cell metabolism 20170209 3
Type 1 diabetes (T1D) is a chronic autoimmune disease that involves immune-mediated destruction of β cells. How β cells respond to immune attack is unknown. We identified a population of β cells during the progression of T1D in non-obese diabetic (NOD) mice that survives immune attack. This population develops from normal β cells confronted with islet infiltrates. Pathways involving cell movement, growth and proliferation, immune responses, and cell death and survival are activated in these cell ...[more]
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