MR imaging of a novel NOE-mediated magnetization transfer with water in rat brain at 9.4 T.

ABSTRACT:

Purpose

To detect, map, and quantify a novel nuclear Overhauser enhancement (NOE)-mediated magnetization transfer (MT) with water at approximately -1.6 ppm [NOE(-1.6)] in rat brain using MRI.

Methods

Continuous wave MT sequences with a variety of radiofrequency irradiation powers were optimized to achieve the maximum contrast of this NOE(-1.6) effect at 9.4 T. The distribution of effect magnitudes, resonance frequency offsets, and line widths in healthy rat brains and the differences of the effect between tumors and contralateral normal brains were imaged and quantified using a multi-Lorentzian fitting method. MR measurements on reconstituted model phospholipids as well as two cell lines (HEK293 and 9L) were also performed to investigate the possible molecular origin of this

SUBMITTER: Zhang XY 

PROVIDER: S-EPMC5342948 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature