Fourier Analysis of Conservation Patterns in Protein Secondary Structure.

ABSTRACT: Residue conservation is a common observation in alignments of protein families, underscoring positions important in protein structure and function. Though many methods measure the level of conservation of particular residue positions, currently we do not have a way to study spatial oscillations occurring in protein conservation patterns. It is known that hydrophobicity shows spatial oscillations in proteins, which is characterized by computing the hydrophobic moment of the protein domains. Here, we advance the study of moments of conservation of protein families to know whether there might exist spatial asymmetry in the conservation patterns of regular secondary structures. Analogous to the hydrophobic moment, the conservation moment is defined as the modulus of the Fourier transform of th

SUBMITTER: Palaniappan A 

PROVIDER: S-EPMC5342988 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature