Baicalin Protects Mice from Lethal Infection by Enterohemorrhagic Escherichia coli.

ABSTRACT: Shiga-like toxin-producing Escherichia coli (STEC) O157:H7 poses grave challenges to public health by its ability to cause severe colonic diseases and renal failure in both human and animals. Shiga-like toxins are the major pathogenic factor for some highly virulent E. coli expecially Shiga-like toxin 2. Conventional treatments such as antibiotics can facilitate the release of the toxin thus potentially exacerbate the diseases. Small molecule inhibitors and antibodies capable of neutralizing the toxins are the two major venues for the development of therapeutics against enterohemorrhagic serotype E. coli infection. While promising and potentially effective at clinical settings, these approaches need to overcome obstacles such as the limited routes of administration, re

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC5343029 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature