A new parallel pipeline for DNA methylation analysis of long reads datasets.

ABSTRACT:

Background

DNA methylation is an important mechanism of epigenetic regulation in development and disease. New generation sequencers allow genome-wide measurements of the methylation status by reading short stretches of the DNA sequence (Methyl-seq). Several software tools for methylation analysis have been proposed over recent years. However, the current trend is that the new sequencers and the ones expected for an upcoming future yield sequences of increasing length, making these software tools inefficient and obsolete.

Results

In this paper, we propose a new software based on a strategy for methylation analysis of Methyl-seq sequencing data that requires much shorter execution times while yielding a better level of sensitivity, particularly for datasets composed of long re

SUBMITTER: Olanda R 

PROVIDER: S-EPMC5343294 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature