Perilipin polymorphisms are risk factors for the development of obesity in adolescents? A case-control study.

ABSTRACT:

Background

The variations in perilipin gene (PLIN) were previously associated with obesity. We examined the association of polymorphisms at the PLIN locus in adolescents with obesity and their connection with serum adipokines.

Methods

A total of 308 children (206 obese, 66.8% and 102 healthy control, 33.2%) between the ages of 10-18 years were included into the study. PLIN gene analysis [PLIN 1, PLIN 4, PLIN 6, PLIN 5'UTR-1234 C > G and PLIN 10171 A/T] were studied by Real Time-PCR. Serum leptin, adiponectin, resistin and ghrelin levels were studied by ELISA method in both groups and their link with perilipin polymorphisms were analyzed.

Results

Serum leptin level was found significantly high in obese adolescents. Other adipokine levels were similar in both groups. Th

SUBMITTER: Tokgoz Y 

PROVIDER: S-EPMC5343409 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature