A potential regulatory network underlying distinct fate commitment of myogenic and adipogenic cells in skeletal muscle.

ABSTRACT: Mechanism controlling myo-adipogenic balance in skeletal muscle is of great significance for human skeletal muscle dysfunction and myopathies as well as livestock meat quality. In the present study, two cell subpopulations with particular potency of adipogenic or myogenic differentiation were isolated from neonatal porcine longissimus dorsi using the preplate method to detect mechanisms underlying distinct fate commitment of myogenic and adipogenic cells in skeletal muscle. Both cells share a common surface expression profile of CD29⁺CD31^-CD34^-CD90⁺CD105⁺, verifying their mesenchymal origin. A total of 448 differentially expressed genes (DEGs) (FDR < 0.05 and |log₂ FC| ≥ 1) between two distinct cells were identified via RNA-

SUBMITTER: Sun W 

PROVIDER: S-EPMC5343460 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature