Epilepsy and intellectual disability linked protein Shrm4 interaction with GABA_BRs shapes inhibitory neurotransmission.

ABSTRACT: Shrm4, a protein expressed only in polarized tissues, is encoded by the KIAA1202 gene, whose mutations have been linked to epilepsy and intellectual disability. However, a physiological role for Shrm4 in the brain is yet to be established. Here, we report that Shrm4 is localized to synapses where it regulates dendritic spine morphology and interacts with the C terminus of GABA_B receptors (GABA_BRs) to control their cell surface expression and intracellular trafficking via a dynein-dependent mechanism. Knockdown of Shrm4 in rat severely impairs GABA_BR activity causing increased anxiety-like behaviour and susceptibility to seizures. Moreover, Shrm4 influences hippocampal excitability by modulating tonic inhibition in dentate gyrus granule cells, in a process i

SUBMITTER: Zapata J 

PROVIDER: S-EPMC5343488 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature