A Universal Vaccine against Leptospirosis: Are We Going in the Right Direction?

ABSTRACT: Leptospirosis is the most widespread zoonosis in the world and a neglected tropical disease estimated to cause severe infection in more than one million people worldwide every year that can be combated by effective immunization. However, no significant progress has been made on the leptospirosis vaccine since the advent of bacterins over 100 years. Although protective against lethal infection, particularly in animals, bacterin-induced immunity is considered short term, serovar restricted, and the vaccine can cause serious side effects. The urgent need for a new vaccine has motivated several research groups to evaluate the protective immune response induced by recombinant vaccines. Significant protection has been reported with several promising outer membrane proteins, including LipL32 and

SUBMITTER: Grassmann AA 

PROVIDER: S-EPMC5343615 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature