Advances in Molecular Imaging of Locally Delivered Targeted Therapeutics for Central Nervous System Tumors.

ABSTRACT: Thanks to the recent advances in the development of chemotherapeutics, the morbidity and mortality of many cancers has decreased significantly. However, compared to oncology in general, the field of neuro-oncology has lagged behind. While new molecularly targeted chemotherapeutics have emerged, the impermeability of the blood-brain barrier (BBB) renders systemic delivery of these clinical agents suboptimal. To circumvent the BBB, novel routes of administration are being applied in the clinic, ranging from intra-arterial infusion and direct infusion into the target tissue (convection enhanced delivery (CED)) to the use of focused ultrasound to temporarily disrupt the BBB. However, the current system depends on a "wait-and-see" approach, whereby drug delivery is deemed successful only when a

SUBMITTER: Tosi U 

PROVIDER: S-EPMC5343886 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature