Identification of Autophagy-Related Genes and Their Regulatory miRNAs Associated with Celiac Disease in Children.

ABSTRACT: Celiac disease (CD) is a severe genetic autoimmune disorder, affecting about one in 100 people, where the ingestion of gluten leads to damage in the small intestine. Diagnosing CD is quite complex and requires blood tests and intestinal biopsy examinations. Controversy exists regarding making the diagnosis without biopsy, due to the large spectrum of manifesting symptoms; furthermore, small-intestinal gastroscopy examinations have a relatively complex management in the pediatric population. To identify novel molecular markers useful to increase the sensitivity and specificity in the diagnosis of pediatric CD patients, the expression levels of two key autophagy executor genes (ATG7 and BECN1) and their regulatory validated miRNAs (miR-17 and miR-30a, respectively) were analyzed by relative

SUBMITTER: Comincini S 

PROVIDER: S-EPMC5343926 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature