Multimodal MRI profiling of focal cortical dysplasia type II.

ABSTRACT:

Objective

To characterize in vivo MRI signatures of focal cortical dysplasia (FCD) type IIA and type IIB through combined analysis of morphology, intensity, microstructure, and function.

Methods

We carried out a multimodal 3T MRI profiling of 33 histologically proven FCD type IIA (9) and IIB (24) lesions. A multisurface approach operating on manual consensus labels systematically sampled intracortical and subcortical lesional features. Geodesic distance mapping quantified the same features in the lesion perimeter. Logistic regression assessed the relationship between MRI and histology, while supervised pattern learning was used for individualized subtype prediction.

Results

FCD type IIB was characterized by abnormal morphology, intensity, diffusivity, and function acr

SUBMITTER: Hong SJ 

PROVIDER: S-EPMC5344077 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature