The BCL-2 pro-survival protein A1 is dispensable for T cell homeostasis on viral infection.

ABSTRACT: The physiological role of the pro-survival BCL-2 family member A1 has been debated for a long time. Strong mRNA induction in T cells on T cell receptor (TCR)-engagement suggested a major role of A1 in the survival of activated T cells. However, the investigation of the physiological roles of A1 was complicated by the quadruplication of the A1 gene locus in mice, making A1 gene targeting very difficult. Here, we used the recently generated A1^-/- mouse model to examine the role of A1 in T cell immunity. We confirmed rapid and strong induction of A1 protein in response to TCR/CD3 stimulation in CD4⁺ as well as CD8⁺ T cells. Surprisingly, on infection with the acute influenza HKx31 or the lymphocytic choriomeningitis virus docile strains mice lacking A1 did not

SUBMITTER: Tuzlak S 

PROVIDER: S-EPMC5344212 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature