HGF Modulates Actin Cytoskeleton Remodeling and Contraction in Testicular Myoid Cells.

ABSTRACT: The presence of the HGF/Met system in the testicular myoid cells was first discovered by our group. However, the physiological role of this pathway remains poorly understood. We previously reported that HGF increases uPA secretion and TGF-β activation in cultured tubular fragments and that HGF is maximally expressed at Stages VII-VIII of the seminiferous epithelium cycle, when myoid cell contraction occurs. It is well known that the HGF/Met pathway is involved in cytoskeletal remodeling; moreover, the interaction of uPA with its receptor, uPAR, as well as the activation of TGF-β have been reported to be related to the actin cytoskeleton contractility of smooth muscle cells. Herein, we report that HGF induces actin cytoskeleton remodeling in vitro in isolated myoid cells and myoid cell cont

SUBMITTER: Catizone A 

PROVIDER: S-EPMC5344232 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature