Recent Innovations in Peptide Based Targeted Drug Delivery to Cancer Cells.

ABSTRACT: Targeted delivery of chemotherapeutics and diagnostic agents conjugated to carrier ligands has made significant progress in recent years, both in regards to the structural design of the conjugates and their biological effectiveness. The goal of targeting specific cell surface receptors through structural compatibility has encouraged the use of peptides as highly specific carriers as short peptides are usually non-antigenic, are structurally simple and synthetically diverse. Recent years have seen many developments in the field of peptide based drug conjugates (PDCs), particularly for cancer therapy, as their use aims to bypass off-target side-effects, reducing the morbidity common to conventional chemotherapy. However, no PDCs have as yet obtained regulatory approval. In this review, we de

SUBMITTER: Gilad Y 

PROVIDER: S-EPMC5344250 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature