Leptin concentration and risk of coronary heart disease and stroke: A systematic review and meta-analysis.

ABSTRACT:

Background and purpose

Although high leptin concentration has been shown to be correlated with established vascular risk factors, epidemiologic studies have reported inconclusive results on the association between leptin and cardiovascular diseases (CVD). Therefore, a meta-analysis was performed to evaluate this issue.

Methods

We searched Pubmed, Embase, and the Cochrane Library from their inception to Jan 2016 for both case-control and cohort studies that assessed leptin concentration and CVD risk. Reports with odds ratio (OR), risk ratio (RR) and corresponding 95% confidence intervals (CI) were considered. The data were extracted by two investigators independently.

Results

A total of 13 epidemiologic studies totaling 4257 CVD patients and 26710 controls were include

SUBMITTER: Yang H 

PROVIDER: S-EPMC5344319 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature