Association of genetic variations in the mitochondrial DNA control region with presbycusis.

ABSTRACT:

Background

The prominent role of mitochondria in the generation of reactive oxygen species, cell death, and energy production contributes to the importance of this organelle in the intracellular mechanism underlying the progression of the common sensory disorder of the elderly, presbycusis. Reduced mitochondrial DNA (mtDNA) gene expression and coding region variation have frequently been reported as being associated with the development of presbycusis. The mtDNA control region regulates gene expression and replication of the genome of this organelle. To comprehensively understand of the role of mitochondria in the progression of presbycusis, we compared variations in the mtDNA control region between subjects with presbycusis and controls.

Methods

A total of 58 presbycusis pa

SUBMITTER: Falah M 

PROVIDER: S-EPMC5344408 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature