Intrinsic signal optical imaging of visual brain activity: Tracking of fast cortical dynamics.

ABSTRACT: Hemodynamic-based brain imaging techniques are typically incapable of monitoring brain activity with both high spatial and high temporal resolutions. In this study, we have used intrinsic signal optical imaging (ISOI), a relatively high spatial resolution imaging technique, to examine the temporal resolution of the hemodynamic signal. We imaged V1 responses in anesthetized monkey to a moving light spot. Movies of cortical responses clearly revealed a focus of hemodynamic response traveling across the cortical surface. Importantly, at different locations along the cortical trajectory, response timecourses maintained a similar tri-phasic shape and shifted sequentially across cortex with a predictable delay. We calculated the time between distinguishable timecourses and found that the tempora

SUBMITTER: Lu HD 

PROVIDER: S-EPMC5344706 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature