A Perspective on the Development of Plant-Made Vaccines in the Fight against Ebola Virus.

ABSTRACT: The Ebola virus (EBOV) epidemic indicated a great need for prophylactic and therapeutic strategies. The use of plants for the production of biopharmaceuticals is a concept being adopted by the pharmaceutical industry, with an enzyme for human use currently commercialized since 2012 and some plant-based vaccines close to being commercialized. Although plant-based antibodies against EBOV are under clinical evaluation, the development of plant-based vaccines against EBOV essentially remains an unexplored area. The current technologies for the production of plant-based vaccines include stable nuclear expression, transient expression mediated by viral vectors, and chloroplast expression. Specific perspectives on how these technologies can be applied for developing anti-EBOV vaccines are provide

SUBMITTER: Rosales-Mendoza S 

PROVIDER: S-EPMC5344899 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature