Health-Associated Niche Inhabitants as Oral Probiotics: The Case of Streptococcus dentisani.

ABSTRACT: Oral diseases, including dental caries and periodontitis, are among the most prevalent diseases worldwide and develop as a consequence of a microbial dysbiosis. Several bacterial strains are being tested as potential oral health-promoting organisms, but usually they are species isolated from niches other than the site where they must exert its probiotic action, typically from fecal samples. We hypothesize that oral inhabitants associated to health conditions will be more effective than traditional, gut-associated probiotic species in key aspects such as colonization of the oral site where disease takes place or the possession of oral health promoting functions, as well as more practical issues like safety and toxicity, and establishing proper doses for administration. As an example of thes

SUBMITTER: Lopez-Lopez A 

PROVIDER: S-EPMC5344910 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature