Intensive Blood-Pressure Lowering in Patients with Acute Cerebral Hemorrhage.

ABSTRACT:

Background

Limited data are available to guide the choice of a target for the systolic blood-pressure level when treating acute hypertensive response in patients with intracerebral hemorrhage.

Methods

We randomly assigned eligible participants with intracerebral hemorrhage (volume, <60 cm(3)) and a Glasgow Coma Scale (GCS) score of 5 or more (on a scale from 3 to 15, with lower scores indicating worse condition) to a systolic blood-pressure target of 110 to 139 mm Hg (intensive treatment) or a target of 140 to 179 mm Hg (standard treatment) in order to test the superiority of intensive reduction of systolic blood pressure to standard reduction; intravenous nicardipine to lower blood pressure was administered within 4.5 hours after symptom onset. The primary outcome was death

SUBMITTER: Qureshi AI 

PROVIDER: S-EPMC5345109 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature