Prediction of virus-host protein-protein interactions mediated by short linear motifs.

ABSTRACT:

Background

Short linear motifs in host organisms proteins can be mimicked by viruses to create protein-protein interactions that disable or control metabolic pathways. Given that viral linear motif instances of host motif regular expressions can be found by chance, it is necessary to develop filtering methods of functional linear motifs. We conduct a systematic comparison of linear motifs filtering methods to develop a computational approach for predicting motif-mediated protein-protein interactions between human and the human immunodeficiency virus 1 (HIV-1).

Results

We implemented three filtering methods to obtain linear motif sets: 1) conserved in viral proteins (C), 2) located in disordered regions (D) and 3) rare or scarce in a set of randomized viral sequences (R). The

SUBMITTER: Becerra A 

PROVIDER: S-EPMC5345135 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature